Stenfors L E, Bye H M, Räisänen S, Myklebust R
Department of Otolaryngology, University of Tromsö, Tromsö, Norway.
J Laryngol Otol. 2000 Nov;114(11):848-52. doi: 10.1258/0022215001904149.
Bacterial penetration into epithelial cells, scraped from the palatine tonsils of 14 patients (10 males, four females; median age 16 years) with current infectious mononucleosis and concomitant membranous tonsillitis, was studied using the transmission electron microscopic (TEM) technique. Bacteria were seen to adhere to and penetrate the epithelial cells, some of which were completely filled with bacteria. This finding suggests intracellular proliferation of bacteria. Epstein-Barr virus, the causative agent of infectious mononucleosis, especially when associated with growth of beta-haemolytic streptococci on the palatine tonsils, induces bacterial penetration into tonsillar tissue, that in turn might be a causative mechanism in the development of peritonsillar abscess.
采用透射电子显微镜（TEM）技术，研究了从14例患有当前传染性单核细胞增多症并伴有膜性扁桃体炎的患者（10名男性，4名女性；中位年龄16岁）腭扁桃体刮取的上皮细胞中细菌的穿透情况。可见细菌黏附并穿透上皮细胞，其中一些上皮细胞完全被细菌填满。这一发现提示细菌在细胞内增殖。传染性单核细胞增多症的病原体——爱泼斯坦-巴尔病毒，尤其是当与腭扁桃体上β-溶血性链球菌生长相关时，会诱导细菌穿透扁桃体组织，这反过来可能是扁桃体周围脓肿形成的致病机制。
