雾化吸入乙酰半胱氨酸和生理盐水治疗开胸术后痰液潴留的疗效评估
Evaluation of nebulised acetylcysteine and normal saline in the treatment of sputum retention following thoracotomy.
作者信息
Gallon A M
机构信息
Norfolk and Norwich Health Care NHS Trust, UK.
出版信息
Thorax. 1996 Apr;51(4):429-32. doi: 10.1136/thx.51.4.429.
BACKGROUND
The use of acetylcysteine as a mucolytic agent is controversial. In 1962 it was claimed to be "the most effective agent ... for the liquefaction of ... secretions" but was subsequently taken off the market as a respirator solution. Normal saline, on the other hand, is becoming increasingly popular. A study was undertaken to determine which solution is more effective at clearing retained secretions following thoracotomy.
METHODS
The study included 10 patients and was of single blind, two-way crossover design. Measurements taken before and after each treatment included sputum viscosity, difficulty of expectoration, weight of sputum expectorated, and oxygen saturation.
RESULTS
Following nebulisation of acetylcysteine, sputum viscosity was reduced, difficulty of expectoration was reduced, the weight of sputum expectorated was increased, and oxygen saturation was increased. There were no changes after nebulisation of normal saline.
CONCLUSIONS
This study shows that, following thoracotomy, nebulised acetylcysteine reduces sputum viscosity, making expectoration easier and improving oxygenation. Nebulised normal saline has no effect.
背景
乙酰半胱氨酸作为黏液溶解剂的使用存在争议。1962年，它被宣称是“用于……分泌物液化的最有效药物”，但随后作为呼吸溶液被撤市。另一方面，生理盐水正变得越来越受欢迎。开展了一项研究以确定哪种溶液在清除开胸术后潴留的分泌物方面更有效。
方法
该研究纳入了10名患者，采用单盲、双向交叉设计。每次治疗前后进行的测量包括痰液黏稠度、咳痰难度、咳出痰液的重量和血氧饱和度。
结果
雾化吸入乙酰半胱氨酸后，痰液黏稠度降低，咳痰难度降低，咳出痰液的重量增加，血氧饱和度增加。雾化吸入生理盐水后无变化。
结论
本研究表明，开胸术后，雾化吸入乙酰半胱氨酸可降低痰液黏稠度，使咳痰更容易并改善氧合。雾化吸入生理盐水无效。
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