浅表角膜损伤的局部镇痛
Topical analgesia for superficial corneal injuries.
作者信息
Brahma A K, Shah S, Hillier V F, McLeod D, Sabala T, Brown A, Marsden J
机构信息
Royal Eye Hospital, Manchester, United Kingdom.
出版信息
J Accid Emerg Med. 1996 May;13(3):186-8. doi: 10.1136/emj.13.3.186.
OBJECTIVE
To assess the analgesic effects of a topical non-steroidal anti-inflammatory agent, flurbiprofen 0.03%, during healing after superficial corneal injuries.
METHODS
401 patients treated for corneal abrasion in a five month period were randomly allocated to one of four treatment groups: polyvinyl alcohol alone (control), homatropine 2%, flurbiprofen 0.03%, or homatropine 2% followed by flurbiprofen 0.03%. Treatments were given for 48 h. Ocular pain was recorded on a visual analogue scale by the patients over the first 24 h, and use of oral analgesics was also recorded. Usable responses were received from 224 patients (55.8%).
RESULTS
Patients treated with flurbiprofen had significantly lower pain scores for the 24 h duration of the study than controls (P < 0.05).
CONCLUSIONS
Flurbiprofen eye drops provide more effective pain relief than traditional treatments for superficial corneal injuries.
目的
评估局部用非甾体抗炎药0.03%氟比洛芬在浅表角膜损伤愈合过程中的镇痛效果。
方法
在五个月期间接受角膜擦伤治疗的401例患者被随机分配至四个治疗组之一：单独使用聚乙烯醇（对照组）、2%后马托品、0.03%氟比洛芬，或先使用2%后马托品再使用0.03%氟比洛芬。治疗持续48小时。患者在最初24小时内通过视觉模拟量表记录眼部疼痛情况，同时记录口服镇痛药的使用情况。224例患者（55.8%）提供了可用的反应。
结果
在研究的24小时期间，接受氟比洛芬治疗的患者疼痛评分显著低于对照组（P < 0.05）。
结论
对于浅表角膜损伤，氟比洛芬滴眼液比传统治疗方法能提供更有效的疼痛缓解。
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