与安慰剂相比，5%的阿托品是否能有效减轻角膜擦伤引起的疼痛？一项随机对照试验。

Is homatropine 5% effective in reducing pain associated with corneal abrasion when compared with placebo? A randomized controlled trial.

机构信息

Emergency Department, Dandenong Hospital, David Street, Dandenong, Vic. 3101, Australia.

出版信息

Emerg Med Australas. 2010 Dec;22(6):507-13. doi: 10.1111/j.1742-6723.2010.01346.x.

DOI:10.1111/j.1742-6723.2010.01346.x

PMID:21143399

Abstract

OBJECTIVE

To compare the change in visual analogue scale (VAS) pain ratings over 24 h following mechanical corneal abrasion between patients receiving sixth hourly drops of either 5% homatropine or placebo.

METHODS

A triple blind randomized controlled trial was conducted on a convenience sample of eligible consenting adults who were randomized to receive either sixth hourly 5% homatropine (active) or 0.5% hypromellose (placebo) eye drops. VAS pain ratings were performed at 0, 6, 12, 18 and 24 h whereas the study drug was instilled at 0, 6, 12 and 18 h. The primary outcome was attainment of a clinically significant reduction in pain on the VAS (>20 mm decrease) from enrolment to each time point.

RESULTS

There were no significant differences in baseline variables or VAS pain ratings at any time point between those in the homatropine (n= 20) and placebo (n= 20) groups. The percentages of patients reporting a >20 mm VAS decrease at 12 h were 50% (95% CI -27.2-72.8) and 60% (95% CI -36.1-80.9) for the homatropine and placebo groups, respectively.

CONCLUSION

We found no significant difference in pain score reductions between the two groups but some level of therapeutic benefit is not excluded.

摘要

目的

比较接受每 6 小时滴注 5%阿托品或安慰剂的机械性角膜擦伤患者在 24 小时内视觉模拟量表（VAS）疼痛评分的变化。

方法

对符合条件的成年患者进行了一项三盲随机对照试验，将其随机分为接受每 6 小时滴注 5%阿托品（活性）或 0.5%羟丙甲纤维素（安慰剂）的患者。在 0、6、12、18 和 24 小时时进行 VAS 疼痛评分，而在 0、6、12 和 18 小时时滴注研究药物。主要结局是从入组到每个时间点 VAS 疼痛评分（>20mm 下降）达到临床显著缓解。