Mizutani M, Okuda Y, Yamashita K
Department of Internal Medicine, University of Tsukuba, Japan.
Biochem Mol Med. 1996 Apr;57(2):156-8. doi: 10.1006/bmme.1996.0023.
Increased levels of platelet-derived growth factor (PDGF) may play a central role in the development of arteriosclerosis, but the factors that inhibit PDGF production in vascular endothelial cells remain mostly unknown. We examined the effects of cilostazol, an antithrombotic agent, and high glucose on PDGF production in cultured human umbilical vein endothelial cells (HUVEC). HUVEC grown in high glucose exhibits increased PDGF production, which was markedly inhibited by cilostazol. Since cilostazol inhibits PDGF production in HUVEC, its use may exhibit anti-arteriosclerotic effects in diabetic patients.
血小板衍生生长因子（PDGF）水平升高可能在动脉硬化发展过程中起核心作用，但抑制血管内皮细胞中PDGF产生的因素大多仍不为人知。我们研究了抗血栓药物西洛他唑和高糖对培养的人脐静脉内皮细胞（HUVEC）中PDGF产生的影响。在高糖环境中生长的HUVEC表现出PDGF产生增加，而西洛他唑可显著抑制这种增加。由于西洛他唑抑制HUVEC中PDGF的产生，其应用可能对糖尿病患者具有抗动脉硬化作用。
