Mizutani M, Okuda Y, Suzuki S, Sawada T, Soma M, Yamashita K
Department of Internal Medicine, University of Tsukuba, Japan.
Life Sci. 1995;57(2):PL31-5. doi: 10.1016/0024-3205(95)00261-4.
The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3 x 10(-4)M) markedly inhibited PDGF production [27.5 mM glucose group: 123 +/- 3% of control (5.5 mM glucose group), 27.5 mM glucose+EPA group: 104 +/- 5% of control]. These results suggested that a high glucose concentration and a high osmotic pressure-induced increase in PDGF production is involved in the development and progression of diabetic macroangiopathy. As eicosapentaenoic acid inhibits the PDGF production induced by high glucose concentration in HUE, use of this agent may exhibit anti-arteriosclerotic effects.
在培养的人脐静脉内皮细胞（HUE）中研究了血小板衍生生长因子（PDGF）产生的调节以及高糖浓度、二十碳五烯酸（EPA）的影响。HUE中PDGF的产生根据葡萄糖浓度显著增加。然而，EPA（3×10⁻⁴M）显著抑制PDGF的产生[27.5 mM葡萄糖组：为对照组（5.5 mM葡萄糖组）的123±3%，27.5 mM葡萄糖+EPA组：为对照组的104±5%]。这些结果表明，高糖浓度和高渗透压诱导的PDGF产生增加与糖尿病大血管病变的发生和发展有关。由于二十碳五烯酸抑制HUE中高糖浓度诱导的PDGF产生，使用该药物可能具有抗动脉粥样硬化作用。
