通过低剂量钆喷酸葡胺在团注过程中的弛豫效应测量脑血容量。
Measurement of cerebral blood volume via the relaxing effect of low-dose gadopentetate dimeglumine during bolus transit.
作者信息
Hackländer T, Reichenbach J R, Hofer M, Mödder U
机构信息
Department of Diagnostic Radiology, Heinrich-Heine-Universität, Düsseldorf, Germany.
出版信息
AJNR Am J Neuroradiol. 1996 May;17(5):821-30.
PURPOSE
To quantify regional cerebral blood volume (rCBV) on the basis of the enhancement of blood proton relaxation rates after intravenous administration of gadopentetate dimeglumine.
METHODS
A series of sequential MR images on one section was recorded during bolus transit with a standard fast low-angle shot sequence. The signal-intensity curves were converted into corresponding concentration-time curves from which rCBV images were calculated.
RESULTS
The functional parameter images of rCBV were calculated pixel-by-pixel for two patients who had received a 1-second bolus injection of 1 mmol of gadopentetate dimeglumine. In a larger series of 62 patients, a mean blood volume of 4.6 +/- 1.6 vol% was determined for normal brain tissue.
CONCLUSIONS
The relaxing effect of a contrast agent can be used to determine blood volume quantitatively. The results are in agreement with those obtained by nuclear medicine techniques. The proposed method requires no special hardware, and can thus be implemented on clinical MR scanners.
目的
基于静脉注射钆喷酸葡胺后血质子弛豫率的增强来定量测定局部脑血容量（rCBV）。
方法
在团注过程中，用标准快速低角度激发序列在一个层面上记录一系列连续的磁共振图像。将信号强度曲线转换为相应的浓度 - 时间曲线，由此计算rCBV图像。
结果
对两名接受1秒团注1 mmol钆喷酸葡胺的患者逐像素计算rCBV的功能参数图像。在62例更大样本的患者中，正常脑组织的平均血容量测定为4.6±1.6体积％。
结论
造影剂的弛豫作用可用于定量测定血容量。结果与核医学技术获得的结果一致。所提出的方法不需要特殊硬件，因此可在临床磁共振扫描仪上实施。
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