Seifert J
Fortschr Med. 1977 Jun 2;95(21):1376-80.
In spite of modern therapeutical concepts chronic osteomyelitis is a disease, which can be resistant to all trials with antibiotics, surgical or other treatments. Since the percentage of bone infections increases by increasing accidents the possibilities of classical treatment are discussed and new therapeutical ideas developed by considerations regarding the pathomechanism. The basical reflections for this new treatment can be summarized with the fact that a chronic infection can only develop in an organism with a lack of immune resistance. As the immune response of an organism can be stimulated by vaccination there is a high possibility to overcome a chronic infection by a vaccination procedure. In fact, first therapeutical results confirm this consideration in chronic osteomyelitis.
尽管有现代治疗理念，但慢性骨髓炎仍是一种对抗生素、手术或其他治疗方法都可能产生耐药性的疾病。由于随着事故增多，骨感染的比例上升，因此人们讨论了传统治疗方法的可能性，并根据病理机制的考虑提出了新的治疗思路。这种新治疗方法的基本思路可以概括为，慢性感染只会在免疫抵抗力不足的机体中发生。由于接种疫苗可以刺激机体的免疫反应，因此通过接种疫苗程序克服慢性感染的可能性很大。事实上，初步的治疗结果证实了这一针对慢性骨髓炎的思路。
