Butugan O, Sanchez T G, Gonçalez F, Venosa A R, Miniti A
Otolaryngology Department, University of Sao Paulo School of Medicine.
Rev Laryngol Otol Rhinol (Bord). 1996;117(1):53-5.
Mucormycosis is the most acutely fatal fungal infection of the human being (5). Although relatively uncommon, its morbidity makes it an extremely important disease for the Otolaryngologist-Head and Neck Surgeon. A review of 11 cases of rhinocerebral mucormycosis (nine female and two male patients) admitted from 1961 to 1994 at Hospital das Clinicas, University of Sao Paulo was undertaken. The age range was from eight months to 49 years with a median age of 31 years. In the current study, we present and discuss the predisposing factors, the methods of diagnosis, the treatment given the complications observed and the survival of the disease. The survival rate for paranasal sinus mucormycosis in this study was 72.7% (8/11). All deaths occured within the first month after diagnosis and institution of treatment. All the patients that died presented with diabetic ketoacidosis. Hemiplegia as a neurological complication of the disease was seen in 66.6% (2/3) of the deaths. Survival analysis (Fisher Test p < 0.05) indicates that diabetic ketoacidosis and hemiplegia are negative prognostic factors in mucormycosis survival. The authors intend to add some more information to the limited literature on paranasal sinus mucormycosis.
毛霉病是人类最具急性致死性的真菌感染（5）。尽管相对不常见，但其发病率使其成为耳鼻喉头颈外科医生极为重要的一种疾病。我们对1961年至1994年期间圣保罗大学临床医院收治的11例鼻脑型毛霉病患者（9例女性和2例男性）进行了回顾。年龄范围为8个月至49岁，中位年龄为31岁。在本研究中，我们展示并讨论了易感因素、诊断方法、针对观察到的并发症所采取的治疗措施以及该疾病的生存率。本研究中鼻窦毛霉病的生存率为72.7%（8/11）。所有死亡均发生在诊断和开始治疗后的第一个月内。所有死亡患者均患有糖尿病酮症酸中毒。偏瘫作为该疾病的一种神经并发症，在66.6%（2/3）的死亡病例中出现。生存分析（Fisher检验p<0.05）表明，糖尿病酮症酸中毒和偏瘫是毛霉病生存的不良预后因素。作者旨在为关于鼻窦毛霉病的有限文献增添更多信息。
