Schander K, Rehm A, Niesen M
Fortschr Med. 1977 Jun 9;95(22):1477-81.
In two groups of 35 healthy and 15 asphyctic newborns the factors of blood coagulation and fibrinolysis were determined and compared with the normal values of non-pregnant women. The study demonstrates an increased coagulability and increased fibrinolytic activity at decreased levels of most of the single factors in the umbilical vein blood of the newborn. There is a statistically significant decrease of the concentration of plasminogen and increase of the concentration of fibrin degradation products and fibrin monomers in the groups of asphyctic newborns as compared with healthy newborns. These results may be considered as factors in the etiology of the respiratory distress syndrome of the newborn resulting in the formation of hyaline membranes. An increased tendency to hemorrhages in asphyctic newborn due to a hypocoagulation of the umbilical vein blood cannot be suggested by these results. The study confirms and supplements previous research findings from our laboratory and from others reported in the literature.
在两组分别为35名健康新生儿和15名窒息新生儿中，测定了血液凝固和纤维蛋白溶解因子，并与未怀孕女性的正常值进行了比较。研究表明，新生儿脐静脉血中大多数单一因子水平降低时，其凝血性增加，纤维蛋白溶解活性增强。与健康新生儿相比，窒息新生儿组中纤溶酶原浓度有统计学意义的降低，纤维蛋白降解产物和纤维蛋白单体浓度增加。这些结果可被视为新生儿呼吸窘迫综合征病因中的因素，导致透明膜的形成。这些结果不能表明窒息新生儿因脐静脉血低凝而有出血倾向增加。该研究证实并补充了我们实验室之前的研究结果以及文献中报道的其他研究结果。
