Kay L, Jørgensen T
Medical Dept. C, Glostrup County Hospital, University of Copenhagen, Denmark.
Scand J Gastroenterol. 1996 May;31(5):469-75. doi: 10.3109/00365529609006767.
Gastroenterologists use different definitions of irritable bowel syndrome and upper dyspepsia, and the different definitions select different populations with the syndromes. The aim of the study was, in an unselected population, to find combinations of abdominal symptoms that occur together more often than can be expected by chance and thereby find statistical support for standard definitions of the syndromes.
A sex- and age-stratified random sample of 4851 Danes living in the western part of Copenhagen was interviewed about abdominal symptoms. Five years later an identical interview was carried out among the participants.
The participation rate was 79% in the first study and 85% in the second. Independent of age, sex, and time, the following three definitions describe subjects with symptoms occurring together more often than could be expected by chance: 1) Subjects stating that they often experience both abdominal pain and distension and, additionally, either borborygmi or altering stool consistency. This combination occurred with a prevalence of 3.2% among men and 7.5% among women; 2) Subjects stating that they experience all of the following three symptoms: abdominal pain, heartburn, and acid regurgitation. This combination occurred with a prevalence of 1.3% among men and 0.8% among women; 3) Subjects stating that they often experience both nausea and abdominal pain. This combination occurred with a prevalence of 0.9% among men and 3.6% among women.
It is suggested that these three definitions should be used as standards for irritable bowel syndrome, upper dyspepsia-heart burn type and upper dyspepsia-nausea type, respectively.
胃肠病学家对肠易激综合征和上消化道消化不良采用不同的定义，而不同的定义所选取的患有这些综合征的人群也不同。本研究的目的是在一个未经过筛选的人群中，找出比偶然预期更常同时出现的腹部症状组合，从而为这些综合征的标准定义找到统计学依据。
对居住在哥本哈根西部的4851名丹麦人进行了按性别和年龄分层的随机抽样，询问他们的腹部症状。五年后，对参与者进行了相同的访谈。
第一项研究的参与率为79%，第二项为85%。与年龄、性别和时间无关，以下三种定义所描述的有症状的受试者同时出现的频率高于偶然预期：1）受试者表示他们经常同时经历腹痛和腹胀，此外，还有肠鸣或大便性状改变。这种组合在男性中的患病率为3.2%，在女性中为7.5%；2）受试者表示他们经历以下所有三种症状：腹痛、烧心和反酸。这种组合在男性中的患病率为1.3%，在女性中为0.8%；3）受试者表示他们经常同时经历恶心和腹痛。这种组合在男性中的患病率为0.9%，在女性中为3.6%。
建议将这三种定义分别用作肠易激综合征、上消化道消化不良烧心型和上消化道消化不良恶心型的标准。
