Heikius B, Niemelä S, Lehtola J, Karttunen T, Lähde S
Dept. of Internal Medicine, University Hospital of Oulu, Finland.
Scand J Gastroenterol. 1996 May;31(5):517-23. doi: 10.3109/00365529609006775.
We performed a cross-sectional study to estimate the prevalence of duct abnormalities and exocrine pancreatic dysfunction in an unselected group of patients with inflammatory bowel disease (IBD) and to correlated the findings with clinical, endoscopic, and histologic variables.
A total of 237 IBD patients were screened for pancreatic enzymes and with a PABA test. Seventy-one (30%) patients with values more than twice the upper normal limit in biochemical tests or with a PABA test < 40% were further evaluated. The pancreatic evaluation included endoscopic retrograde pancreatography, ultrasonography, and a secretin test. The endoscopic and histologic findings were systematically evaluated.
The secretin test was completed in 54 patients, and in 10 (19%) it showed a decreased maximal bicarbonate concentration, corresponding to 4% of the whole study group. The pancreatograms of 59 patients were studied. In 20 (34%) patients unequivocal duct abnormalities were found. The prevalence of pancreatic duct abnormalities in IBD was 8.4%.
Our results show the presence of pancreatic duct abnormalities and exocrine pancreatic insufficiency in some patients with IBD.
我们进行了一项横断面研究，以评估一组未经选择的炎症性肠病（IBD）患者中胰腺导管异常和胰腺外分泌功能障碍的患病率，并将研究结果与临床、内镜和组织学变量进行关联。
对总共237例IBD患者进行了胰腺酶筛查和对氨基苯甲酸（PABA）试验。对生化检查值超过正常上限两倍或PABA试验<40%的71例（30%）患者进行了进一步评估。胰腺评估包括内镜逆行胰胆管造影、超声检查和促胰液素试验。对内镜和组织学检查结果进行了系统评估。
54例患者完成了促胰液素试验，其中10例（19%）显示最大碳酸氢盐浓度降低，占整个研究组的4%。对59例患者的胰胆管造影进行了研究。在20例（34%）患者中发现了明确的导管异常。IBD患者中胰腺导管异常的患病率为8.4%。
我们的结果显示部分IBD患者存在胰腺导管异常和胰腺外分泌功能不全。
