Diaz Vega M, De La Cueva P, Leal C, Aisa F
Clínica Ginecológica de Zaragoza, Spain.
Prenat Diagn. 1996 Apr;16(4):307-12. doi: 10.1002/(SICI)1097-0223(199604)16:4<307::AID-PD846>3.0.CO;2-8.
In this study we report the results of 181 ultrasound-guided genetic amniocenteses performed at 10-12 weeks of gestation and describe the indication, technical problems, amniotic fluid volume, culture success and timing, abortion and fetal loss rate, and perinatal results. Amniotic fluid was obtained in 98.4 per cent of the cases; at the first attempt, in 167 out of 181. The culture success rate was 94.5 per cent, and the fetal loss rate within 2 weeks was 0.5 per cent (one case with a sonographic abnormality). The total fetal loss rate during pregnancy was 1.6 per cent. A comparison of our data and those of other published series shows no significant differences, either with respect to this period of gestation (10-12 weeks) or with respect to the traditionally called early amniocentesis' (12-14 weeks) or conventional amniocentesis (15 weeks or more). The mean culture time was just a few days longer in some of the series, and in some cases, there was also a lower success rate after culture, particularly when amniocentesis was carried out at 10 weeks or less. We conclude that amniocentesis performed at 10-12 weeks is feasible, safe, and easy to perform, and provides a real benefit to the pregnant woman.
在本研究中，我们报告了181例于妊娠10 - 12周进行超声引导下基因羊膜腔穿刺术的结果，并描述了其适应证、技术问题、羊水量、培养成功率及时间、流产和胎儿丢失率以及围产期结局。98.4%的病例成功获取羊水；首次尝试时，181例中有167例成功获取。培养成功率为94.5%，2周内胎儿丢失率为0.5%（1例有超声异常）。孕期总胎儿丢失率为1.6%。将我们的数据与其他已发表系列的数据进行比较，发现在妊娠这一时期（10 - 12周）、传统上所谓的“早期羊膜腔穿刺术”（12 - 14周）或传统羊膜腔穿刺术（15周及以上）方面均无显著差异。在某些系列中，平均培养时间仅长几天，且在某些情况下，培养后的成功率也较低，尤其是在10周及以下进行羊膜腔穿刺术时。我们得出结论，在10 - 12周进行羊膜腔穿刺术是可行、安全且易于操作的，对孕妇具有实际益处。
