[100例心脏移植患者的真菌感染]
[Fungal infections in 100 patients subjected to heart transplantation].
作者信息
Uip D E, Amato Neto V, Varejão Strabelli T M, Alcides Bocchi E, Fiorelli A, Stolf N, Bellotti G, Pileggi F, Jatene A D
机构信息
Divisão de Moléstias Infecciosas e Parasitárias e Instituto do Coração do Hospital das Clínicas-FMUSP, São Paulo.
出版信息
Arq Bras Cardiol. 1996 Feb;66(2):65-7.
PURPOSE
To evaluate prevalence, causes, clinical aspects, topography and deaths due to fungal infections diagnosed in a series of patients submitted to heart transplantation.
METHODS
100 consecutive patients submitted to heart transplantation were studied. Follow-up was three to 90 (mean 25.38 +/- 25.97) months. Fungal infections were diagnosed by the Centers for Disease Control criteria.
RESULTS
Forty seven fungal infections were found, with three deaths caused mainly by fungal infection. The most common infection in this series was oral infection by Candida albicans, Acremonium sp, Aspergillus sp, Candida tropicalis, Histoplasma capsulatum and Pneumocystis carinii were also responsible for infections in this patient population.
CONCLUSION
Fungal infections caused three deaths in this series, and were responsible for increased morbidity. The authors suggest prophylactic and therapeutic recommendations.
目的
评估一系列接受心脏移植患者中真菌感染的患病率、病因、临床特征、感染部位及死亡情况。
方法
对100例连续接受心脏移植的患者进行研究。随访时间为3至90（平均25.38±25.97）个月。真菌感染依据疾病控制中心的标准进行诊断。
结果
共发现47例真菌感染，3例死亡主要由真菌感染所致。该系列中最常见的感染是白色念珠菌引起的口腔感染，枝顶孢属、曲霉属、热带念珠菌、荚膜组织胞浆菌和卡氏肺孢子菌也在该患者群体中导致感染。
结论
该系列中真菌感染导致3例死亡，并增加了发病率。作者提出了预防性和治疗性建议。
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