[100例接受心脏移植患者的病毒感染情况]

[Infections caused by virus in 100 patients submitted to heart transplantation].

作者信息

Uip D E, Amato Neto V, Varejão Strabelli T M, Alcides Bocchi E

机构信息

Divisão de Moléstias Infecciosas e Parasitárias e Instituto do Coração do Hospital das Clínicas--FMUSP, São Paulo, SP.

出版信息

Arq Bras Cardiol. 1996 Apr;66(4):199-203.

PMID:8935684

Abstract

PURPOSE

To analyse prevalence, clinical features and organ involvement in viral infections occuring after heart transplantation.

METHODS

One hundred consecutive heart transplantation patients were studied. The follow-up was three to 90 (mean 23.32 +/- 25.97) months. Viral infections were diagnosed using the Center for Disease Control criteria.

RESULTS

Viral infections were responsible for 51 infections, 19.6% of all infections in this patient population. Herpesvirus infection was the most common etiology: 32 (59.25%) of all viral infections were caused by reactivation of or reinfection by cytomegalovirus. Of those infections 27 (84.37%) occurred in the first three weeks following surgery. Only 4 (12.50%) of those showed clinical signs of cytomegalovirus disease. Other herpesvirus causing infections were herpes simplex and varicella-zoster virus.

CONCLUSION

Infections are common after heart transplantation and viral infections of herpesviridae family are important causes of those infections; usually as reactivation in an immune suppressed patient. The most important viral infections were caused by reactivation of or reinfection by cytomegalovirus.

摘要

目的

分析心脏移植术后发生的病毒感染的患病率、临床特征及器官受累情况。

方法

对连续100例心脏移植患者进行研究。随访时间为3至90个月（平均23.32±25.97个月）。采用疾病控制中心的标准诊断病毒感染。

结果

病毒感染导致了51例感染，占该患者群体所有感染的19.6%。疱疹病毒感染是最常见的病因：所有病毒感染中有32例（59.25%）是由巨细胞病毒的再激活或再次感染引起的。其中27例（84.37%）感染发生在术后前三周。这些感染中只有4例（12.50%）出现了巨细胞病毒病的临床症状。其他引起感染的疱疹病毒是单纯疱疹病毒和水痘-带状疱疹病毒。