Giuliano F, Rampin O, Brown K, Courtois F, Benoit G, Jardin A
Service d'Urologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France.
Neurosci Lett. 1996 May 3;209(1):1-4. doi: 10.1016/0304-3940(96)12594-5.
Penile erection can be elicited by various stimuli integrated in the spinal cord and/or higher central nervous structures. The medial preoptic area (MPOA) of the hypothalamus is known to play a key role in the regulation of the male sexual behavior. In anesthetized male rats we performed MPOA stimulation via stereotaxically implanted electrodes or canulae delivering L-glutamate. An erectile response, assessed by an increase of intracavernous pressure (ICP), was recorded during electrical stimulation of the MPOA. Stimulating the posterior region of the MPOA elicited a greater erectile response than stimulation applied to the anterior region. Microinjections of L-glutamate also elicited an ICP increase. Stimulation of MPOA neurons therefore elicits activation of neural pathways controlling penile erection.
阴茎勃起可由整合于脊髓和/或更高中枢神经结构的各种刺激引发。已知下丘脑的内侧视前区（MPOA）在男性性行为调节中起关键作用。在麻醉的雄性大鼠中，我们通过立体定向植入的电极或输送L-谷氨酸的套管对MPOA进行刺激。在对MPOA进行电刺激期间，记录通过海绵体内压（ICP）增加评估的勃起反应。刺激MPOA的后部区域比刺激前部区域引发更大的勃起反应。L-谷氨酸的微量注射也引起ICP增加。因此，刺激MPOA神经元会引发控制阴茎勃起的神经通路的激活。
