阴道毛滴虫和胎儿三毛滴虫的溶血活性。
Hemolytic activity of Trichomonas vaginalis and Tritrichomonas foetus.
作者信息
De Carli G A, Brasseur P, da Silva A C, Wendorff A, Rott M
机构信息
Departamento de Análises, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Mem Inst Oswaldo Cruz. 1996 Jan-Feb;91(1):107-10. doi: 10.1590/s0074-02761996000100019.
The hemolytic activity of live isolates and clones of Trichomonas vaginalis and Tritrichomonas foetus was investigated. The isolates were tested against human erythrocytes. No hemolytic activity was detected by the isolates of T. foetus. Whereas the isolates of T. vaginalis lysed erythrocytes from all human blood groups. No hemolysin released by the parasites could be detected. Our preliminary results suggest that hemolysis depend on the susceptibility of red cell membranes to destabilization and the intervention of cell surface receptors as a mechanism of the hemolytic activity. The mechanism could be subject to strain-species-genera specific variation of trichomonads. The hemolytic activity of T. vaginalis is not due to a hemolysin or to a product of its metabolism. Pretreatment of trichomonads with concanavalin A reduced levels of hemolysis by 40%.
对阴道毛滴虫和胎儿三毛滴虫的活分离株及克隆株的溶血活性进行了研究。将分离株与人红细胞进行测试。未检测到胎儿三毛滴虫分离株的溶血活性。而阴道毛滴虫分离株可溶解所有人类血型的红细胞。未检测到寄生虫释放的溶血素。我们的初步结果表明，溶血取决于红细胞膜对去稳定化的敏感性以及细胞表面受体的干预，这是溶血活性的一种机制。该机制可能因滴虫的菌株-物种-属特异性变异而有所不同。阴道毛滴虫的溶血活性并非由于溶血素或其代谢产物。用伴刀豆球蛋白A预处理滴虫可使溶血水平降低40%。
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