Mills T M, Stopper V S, Reilly C M
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta 30912-3000, USA.
Int J Impot Res. 1996 Mar;8(1):29-34.
The present studies were designed to determine the role of reactive vascular smooth muscle in the regulation of blood flow into and out of the cavernous sinuses during penile erection in castrated and testosterone-treated animals. While the mean arterial pressure and intracavernosal pressure were continuously monitored, vasoactive drugs were injected into the aorta or into the cavernous sinuses during erection. The results show that both a NO releasing vasodilatory drug and an alpha adrenergic agonist significantly affected both mean arterial pressure and intracavernosal pressure when injected into the aorta. However, when these same drugs were injected into the cavernous sinuses, neither drug exerted a significant influence on the erectile response. Based on these studies, we conclude that the flow of blood into the cavernous sinuses during erection is regulated by reactive vascular smooth muscle but the outflow is not under the regulation of reactive vascular smooth muscle. Furthermore, the relaxation of the smooth muscle which controls the flow of blood into the cavernous sinuses during erection may be under partial androgenic control.
本研究旨在确定在去势及睾酮处理的动物阴茎勃起过程中，反应性血管平滑肌在调节海绵窦血流进出方面的作用。在持续监测平均动脉压和海绵体内压的同时，在勃起过程中将血管活性药物注入主动脉或海绵窦。结果显示，当将释放一氧化氮的血管舒张药物和α肾上腺素能激动剂注入主动脉时，二者均对平均动脉压和海绵体内压有显著影响。然而，当将这些相同药物注入海绵窦时，两种药物均未对勃起反应产生显著影响。基于这些研究，我们得出结论，勃起过程中流入海绵窦的血流受反应性血管平滑肌调节，但流出不受反应性血管平滑肌调节。此外，勃起过程中控制流入海绵窦血流的平滑肌舒张可能部分受雄激素控制。
