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水母和海葵毒液对培养的V79细胞的毒性

Toxicity of jellyfish and sea-anemone venoms on cultured V79 cells.

作者信息

Carli A, Bussotti S, Mariottini G L, Robbiano L

机构信息

Istituto di Scienze Ambientali Marine, Cattedra di Planctologia, Università di Genova, Italy.

出版信息

Toxicon. 1996 Apr;34(4):496-500. doi: 10.1016/0041-0101(95)00157-3.

DOI:10.1016/0041-0101(95)00157-3
PMID:8735250
Abstract

Cnidarian toxins exert an influence on human activities and public health. The cytotoxicity of crude toxins (nematocyst and surrounding tissue venom) of Aequorea aequorea, Rhizostoma pulmo and Anemonia sulcata was assessed on V79 cells. Rhizostoma pulmo and Anemonia sulcata crude venoms showed remarkable cytotoxicity and killed all treated cells at highest tested concentration within 2 and 3 hr, respectively. Aequorea aequorea crude venom greatly affected growth rate during long-term experiments. No genotoxic effect was observed.

摘要

刺胞动物毒素会对人类活动和公众健康产生影响。我们评估了维多利亚多管水母、口冠海蜇和沟迎风海葵的粗毒素(刺丝囊及周围组织毒液)对V79细胞的细胞毒性。口冠海蜇和沟迎风海葵的粗毒液表现出显著的细胞毒性,在最高测试浓度下,分别在2小时和3小时内杀死了所有处理过的细胞。在长期实验中,维多利亚多管水母的粗毒液对生长速率有很大影响。未观察到遗传毒性作用。

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