Kutukculer N, Kutlu O, Nisli G, Oztop S, Cetingul N, Caglayan S
Ege University, Faculty of Medicine, Department of Pediatrics, Izmir, Turkey.
Pediatr Hematol Oncol. 1996 May-Jun;13(3):239-45. doi: 10.3109/08880019609030822.
Neutrophil chemotaxis and random migration were evaluated in 21 patients with thalassemia major and 21 healthy controls by a filter technique (Boyden chamber). Chemotactic and random migrations in patient group were found to be defective, which may partially account for the increased susceptibility to infection occasionally observed in these patients. The effects of serum ferritin levels, transferrin saturations that show iron overload, total count of blood transfusions for chronic immunostimulation, desferrioxamine therapy, and splenectomy on these neutrophil functions were examined in thalassemic patients in order to determine whether they are responsible for these defective functions because the mechanism of abnormal neutrophil chemotaxis and random mobility in thalassemic patients is not still clear.
采用滤膜技术（博伊登小室）对21例重型地中海贫血患者和21名健康对照者的中性粒细胞趋化性和随机游走进行了评估。发现患者组的趋化性和随机游走存在缺陷，这可能部分解释了这些患者偶尔出现的感染易感性增加的原因。为了确定血清铁蛋白水平、显示铁过载的转铁蛋白饱和度、慢性免疫刺激的输血总量、去铁胺治疗和脾切除术对这些中性粒细胞功能的影响是否是导致这些功能缺陷的原因，因为重型地中海贫血患者中性粒细胞趋化异常和随机游走异常的机制仍不清楚，所以对重型地中海贫血患者进行了上述研究。
