Lin C C, Chang C H, Yang J J, Namba T, Hattori M
School of Pharmacy, Kaohsiung Medical College, Taiwan, R.O.C.
J Ethnopharmacol. 1996 Jun;52(2):107-11. doi: 10.1016/0378-8741(96)01397-9.
A major component of ethyl acetate (EtOAc) and chloroform (CHCl3) fractions of Ventilago leiocarpa Bunge (Rhamnaceae), emodin, was isolated and exhibited hepatoprotective effects on carbon tetrachloride (CCl4) as well as D-galactosamine (D-GalN)-induced liver damage. The histopathological examination also clearly showed that emodin reduced lymphocyte cells, Kupffer cells, ballooning degeneration, cell necrosis and hyaline degeneration on CCl4 and D-galactosamine-induced tests.
从鼠李科植物光果勾儿茶（Ventilago leiocarpa Bunge）的乙酸乙酯（EtOAc）和氯仿（CHCl3）提取物中分离出的大黄素是主要成分，其对四氯化碳（CCl4）和D-半乳糖胺（D-GalN）诱导的肝损伤具有保肝作用。组织病理学检查还清楚地表明，在CCl4和D-半乳糖胺诱导的试验中，大黄素减少了淋巴细胞、库普弗细胞、气球样变性、细胞坏死和透明变性。
