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Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide.

作者信息

Hase K, Kasimu R, Basnet P, Kadota S, Namba T

机构信息

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

出版信息

Planta Med. 1997 Feb;63(1):22-6. doi: 10.1055/s-2006-957596.

DOI:10.1055/s-2006-957596
PMID:9063092
Abstract

The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

摘要

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