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鼻息肉:药物治疗还是手术治疗?

Nasal polyps: medical or surgical management?

作者信息

Holmberg K, Karlsson G

机构信息

Department of Otorhinolaryngology, Mölndal Hospital, Sweden.

出版信息

Clin Exp Allergy. 1996 May;26 Suppl 3:23-30. doi: 10.1111/j.1365-2222.1996.tb00655.x.

Abstract

Nasal polyposis is considered to be a non-IgE-mediated inflammatory condition of the nose and sinuses, often associated with chronic non-allergic rhinitis, aspirin intolerance and non-allergic asthma. The aetiology of nasal polyposis is unknown. The main symptoms are nasal obstruction and disturbance of the sense of smell. Occlusion of the nasal passage by a few large polyps could be treated by simple polypectomy to help the patient breathe through the nose. Polypectomy per se does not worsen asthma. Other surgical procedures can be performed, depending on the degree of the disease. The aim of surgery is to restore the physiological properties of the nose by making the nose as free from polyps as possible, and to allow drainage of infected sinuses. Complementary medical treatment of polyposis is always necessary, as surgery cannot treat the inflammatory component of the mucosal disease. In this respect, topical corticosteroids have long been the drugs of choice to reduce the size of polyps, to prevent recurrence after surgery, and are often the main treatment for the disease in many patients. Fluticasone propionate has now been shown to be at least as effective as beclomethasone dipropionate as a medical tool in the management of polyposis. Short-term treatment with systemic corticosteroids is an alternative method of inducing remission and controlling nasal polyps. However, in most patients with nasal polyps, treatment consists of both medical and surgical management.

摘要

鼻息肉病被认为是一种非IgE介导的鼻和鼻窦炎症性疾病,常与慢性非过敏性鼻炎、阿司匹林不耐受和非过敏性哮喘相关。鼻息肉病的病因尚不清楚。主要症状是鼻塞和嗅觉障碍。少数大息肉阻塞鼻道可通过简单的息肉切除术治疗,以帮助患者经鼻呼吸。息肉切除术本身不会加重哮喘。根据疾病程度可进行其他外科手术。手术的目的是通过使鼻腔尽可能无息肉来恢复鼻子的生理特性,并使感染的鼻窦得以引流。息肉病的辅助药物治疗总是必要的,因为手术无法治疗黏膜疾病的炎症成分。在这方面,局部用皮质类固醇长期以来一直是减少息肉大小、防止术后复发的首选药物,并且在许多患者中常常是该疾病的主要治疗方法。现在已表明,丙酸氟替卡松作为治疗息肉病的一种药物工具,至少与二丙酸倍氯米松一样有效。全身用皮质类固醇短期治疗是诱导缓解和控制鼻息肉的另一种方法。然而,在大多数鼻息肉患者中,治疗包括药物和手术管理。

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