Thie M, Fuchs P, Denker H W
Institute of Anatomy, University of Essen, Medical School, Germany.
Int J Dev Biol. 1996 Feb;40(1):389-93.
At embryo implantation we are confronted with the fact that uterine and trophoblast epithelium make contact via their apical cell membranes. This epithelium-epithelium adhesion leading to definitive attachment of the embryo to the uterine wall, however, is far from being trivial and has been called a cell biological paradox. It has been proposed that some of the molecular events involved in epithelium-to-mesenchyme transformation might play a role in the interaction between uterine cells and trophoblast. As a mechanism to achieve uterine epithelium adhesiveness for trophoblast it is postulated that uterine cells partially modulate their epithelial phenotype. Data from recent in vitro experiments give support to this hypothesis and suggest that loss of apical-basal cell polarity might prepare the apical cell pole of uterine epithelium for cell-to-cell contact with trophoblast in vivo.
在胚胎着床时，我们面临这样一个事实：子宫上皮和滋养层上皮通过它们的顶端细胞膜相互接触。然而，这种上皮 - 上皮间的黏附导致胚胎最终附着于子宫壁，这绝非易事，并且被称为细胞生物学上的一个悖论。有人提出，上皮 - 间充质转化过程中涉及的一些分子事件可能在子宫细胞与滋养层之间的相互作用中发挥作用。作为一种使子宫上皮对滋养层具有黏附性的机制，推测子宫细胞会部分调节其上皮表型。近期体外实验的数据支持了这一假说，并表明顶端 - 基底端细胞极性的丧失可能使子宫上皮的顶端细胞极在体内为与滋养层的细胞间接触做好准备。
