de Pedro N, Céspedes M V, Delgado M J, Alonso-Bedate M
Departamento de Biología Animal II (Fisiología Animal), Facultad de Ciencias Biológicas, Universidad Complutense, Madrid, Spain.
Peptides. 1996;17(3):421-4. doi: 10.1016/0196-9781(96)00006-x.
The present study evaluated the central effects of selective opioid receptor subtype agonists and antagonists on food intake in satiated goldfish. Significant increases in feeding behavior occurred in goldfish injected with beta-endorphin, the kappa agonist, U-50488, the delta agonist, [D-Pen2,D-Pen5]enkephalin (DPEN), and the mu agonist, [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAMGO). On the other hand, the different receptor antagonists used: nor-binaltorphamine (nor-BNI) for kappa, 7-benzidilidenenaltrexone (BNTX) for delta 1, naltriben for delta 2, beta-funaltrexamine (beta-FNA) for mu, and naloxonazine for mu 1, by themselves, did not modify ingestion or slightly reduced it. The feeding stimulation by beta-endorphin was antagonized by beta-FNA and naloxonazine, but not by nor-BNI, BNTX, or naltriben. These data indicate that the mu-opioid receptor is involved in the modulation of the feeding behavior in goldfish.
本研究评估了选择性阿片受体亚型激动剂和拮抗剂对饱足金鱼食物摄入的中枢作用。注射β-内啡肽、κ激动剂U-50488、δ激动剂[D-青霉胺2，D-青霉胺5]脑啡肽（DPEN）和μ激动剂[D-丙氨酸2，N-甲基苯丙氨酸4，甘氨酸5-醇]脑啡肽（DAMGO）的金鱼出现进食行为显著增加。另一方面，所使用的不同受体拮抗剂：κ受体的nor-纳曲酮（nor-BNI）、δ1受体的7-苯亚甲基纳曲酮（BNTX）、δ2受体的纳曲苄、μ受体的β-氟纳曲胺（β-FNA）以及μ1受体的纳洛嗪单独使用时，并未改变摄食或使其略有减少。β-内啡肽对摄食的刺激作用被β-FNA和纳洛嗪拮抗，但未被nor-BNI、BNTX或纳曲苄拮抗。这些数据表明μ阿片受体参与了金鱼摄食行为的调节。
