Xiao Q, Challis J R, Fraser M, Wlodek M E, Thorburn G D, Cuttita F, Hill D J, St-Pierre S, Spindel E R, McDonald T J
Department of Medicine, University of Western Ontario, London, Canada.
Peptides. 1996;17(3):489-95. doi: 10.1016/0196-9781(96)00003-4.
Large quantities of gastrin-releasing peptide-like immunoreactivity (GRP-LI) are present in ovine pregnancy fluids (allantoic fluid > fetal plasma > esophageal fluid = amniotic fluid = urine > maternal plasma) and in term endometrium (60 +/- 29 pmol.g-1) and myometrium (4.5 +/- 1.2 pmol.g-1). The larger molecular size [greater than GRP (1-27)] of this GRP-LI entity is not due to a GRP binding protein nor to a C-terminal extension of GRP. In contrast, ovine fetal colon extracts appear to contain the usual GRP (1-27) and GRP (18-27) forms. Hence, the uterus, not the fetus, is the probable source of this novel GRP-like peptide. It apparently acts as a hormone in ovine pregnancy and may play an important role in fetal-placental development.
大量的胃泌素释放肽样免疫活性物质（GRP-LI）存在于绵羊妊娠液中（尿囊液>胎儿血浆>食管液 = 羊水 = 尿液>母体血浆）以及足月子宫内膜（60±29 pmol·g-1）和子宫肌层（4.5±1.2 pmol·g-1）中。这种GRP-LI实体较大的分子大小[大于GRP（1-27）]并非由于GRP结合蛋白，也不是由于GRP的C末端延伸。相反，绵羊胎儿结肠提取物似乎含有通常的GRP（1-27）和GRP（18-27）形式。因此，子宫而非胎儿可能是这种新型GRP样肽的来源。它显然在绵羊妊娠中作为一种激素起作用，并且可能在胎儿-胎盘发育中发挥重要作用。
