卡介苗治疗对BALB/c小鼠内脏利什曼病病程的影响。
Effect of treatment with BCG on the course of visceral leishmaniasis in BALB/c mice.
作者信息
Smrkovski L L, Larson C L
出版信息
Infect Immun. 1977 Apr;16(1):249-57. doi: 10.1128/iai.16.1.249-257.1977.
Abstract
Intravenous inoculation of BCG was found to be both prophylactic and therapeutic in BALB/c mice against challenge with amastigotes of Leishmania donovani. Spleens and livers of mice inoculated with BCG maintained total parasite burdens at significantly lower levels when compared to controls. BCG administered intravenously 14 days prior to and on the same day of protozoan challenge was more protective than vaccine given 30 and 14 days prior to challenge. A level of 10(7) viable units of BCG provided more protection against challenge with parasites than did 10(6) viable units. BCG given the same route as the challenge dose of amastigotes provided more protection than if administered via some other route. BCG given to mice with an already established infection was shown to significantly reduce their parasite burdens.
摘要
在BALB/c小鼠中，静脉注射卡介苗对杜氏利什曼原虫无鞭毛体攻击具有预防和治疗作用。与对照组相比，接种卡介苗的小鼠脾脏和肝脏中的总寄生虫负荷维持在显著较低水平。在原生动物攻击前14天和攻击当天静脉注射卡介苗比在攻击前30天和14天给予疫苗更具保护作用。10⁷个活卡介苗单位比10⁶个活卡介苗单位对寄生虫攻击提供了更多保护。与通过其他途径给药相比，以与无鞭毛体攻击剂量相同的途径给予卡介苗提供了更多保护。给已经感染的小鼠注射卡介苗可显著降低其寄生虫负荷。
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