BALB/c小鼠内脏热带利什曼原虫感染的研究。I. 临床特征和细胞变化。
Studies on visceral Leishmania tropica infection in BALB/c mice. I. Clinical features and cellular changes.
作者信息
Djoko-Tamnou J, Leclerc C, Modabber F, Chedid L
出版信息
Clin Exp Immunol. 1981 Dec;46(3):493-8.
Abstract
The visceral and lethal infection produced in BALB/c mice by Leishmania tropica (major) is accompanied by splenomegaly, anaemia and reversal of albumin-to-globulin ratio. The percentages of both B and T cells are decreased in the spleen. The spleen and lymph nodes become populated with large Ig-, Thy 1.2- 'null' cells. The similarity of some of these parameters with those produced in human kala-azar is discussed.
摘要
热带利什曼原虫（硕大利什曼原虫）在BALB/c小鼠中引起的内脏性致死性感染伴有脾肿大、贫血以及白蛋白与球蛋白比例的倒置。脾脏中B细胞和T细胞的百分比均降低。脾脏和淋巴结中出现大量Ig -、Thy 1.2阴性细胞。文中讨论了其中一些参数与人类黑热病所产生参数的相似性。
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