• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Evidence that both the acyl-CoA- and malonyl-CoA binding sites of mitochondrial overt carnitine palmitoyltransferase (CPT I) are exposed on the cytosolic face of the outer membrane.

作者信息

Fraser F, Corstorphine C G, Zammit V A

机构信息

Hannah Research Institute, Ayr, UK.

出版信息

Biochem Soc Trans. 1996 May;24(2):184S. doi: 10.1042/bst024184s.

DOI:10.1042/bst024184s
PMID:8736842
Abstract
摘要

相似文献

1
Evidence that both the acyl-CoA- and malonyl-CoA binding sites of mitochondrial overt carnitine palmitoyltransferase (CPT I) are exposed on the cytosolic face of the outer membrane.有证据表明，线粒体显性肉碱棕榈酰转移酶（CPT I）的酰基辅酶A结合位点和丙二酰辅酶A结合位点都暴露在外膜的胞质面上。
Biochem Soc Trans. 1996 May;24(2):184S. doi: 10.1042/bst024184s.
2
Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane.丙二酰辅酶A结合位点和明显的肉碱棕榈酰转移酶活性位于线粒体外膜的两侧。
Proc Natl Acad Sci U S A. 1987 Jan;84(2):378-82. doi: 10.1073/pnas.84.2.378.
3
Regulation of mitochondrial outer-membrane carnitine palmitoyltransferase (CPT I): role of membrane-topology.线粒体外膜肉碱棕榈酰转移酶（CPT I）的调控：膜拓扑结构的作用
Adv Enzyme Regul. 1997;37:295-317. doi: 10.1016/s0065-2571(96)00015-5.
4
Topology of carnitine palmitoyltransferase I in the mitochondrial outer membrane.肉碱棕榈酰转移酶I在线粒体外膜中的拓扑结构。
Biochem J. 1997 May 1;323 ( Pt 3)(Pt 3):711-8. doi: 10.1042/bj3230711.
5
Re-evaluation of the interaction of malonyl-CoA with the rat liver mitochondrial carnitine palmitoyltransferase system by using purified outer membranes.利用纯化的外膜重新评估丙二酰辅酶A与大鼠肝脏线粒体肉碱棕榈酰转移酶系统的相互作用。
Biochem J. 1990 Apr 1;267(1):85-90. doi: 10.1042/bj2670085.
6
Binding of [14C]malonyl-CoA to rat liver mitochondria after blocking of the active site of carnitine palmitoyltransferase I. Displacement of low-affinity binding by palmitoyl-CoA.肉碱棕榈酰转移酶I活性位点被阻断后，[14C]丙二酰辅酶A与大鼠肝脏线粒体的结合。棕榈酰辅酶A对低亲和力结合的置换。
Biochem J. 1986 Jan 15;233(2):589-93. doi: 10.1042/bj2330589.
7
Carnitine palmitoyltransferase (CPT2) from liver mitochondrial inner membrane becomes inhibitable by malonyl-CoA if reconstituted with outer membrane malonyl-CoA binding protein.如果用外膜丙二酰辅酶A结合蛋白进行重组，来自肝线粒体内膜的肉碱棕榈酰转移酶（CPT2）会被丙二酰辅酶A抑制。
FEBS Lett. 1990 Sep 3;269(2):406-8. doi: 10.1016/0014-5793(90)81204-2.
8
Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation.肝脏肉碱棕榈酰转移酶-I有两个独立的抑制性结合位点来调节脂肪酸氧化。
Biochim Biophys Acta. 1994 May 13;1212(2):245-52. doi: 10.1016/0005-2760(94)90259-3.
9
Topology of hepatic mitochondrial carnitine palmitoyltransferase I.肝脏线粒体肉碱棕榈酰转移酶I的拓扑结构
Adv Exp Med Biol. 1999;466:27-42. doi: 10.1007/0-306-46818-2_3.
10
The relationship of rat liver overt carnitine palmitoyltransferase to the mitochondrial malonyl-CoA binding entity and to the latent palmitoyltransferase.大鼠肝脏显性肉碱棕榈酰转移酶与线粒体丙二酰辅酶A结合实体及潜在棕榈酰转移酶的关系。
Biochem J. 1990 Sep 15;270(3):787-94. doi: 10.1042/bj2700787.

引用本文的文献

1
The role of genetic defects in carnitine-associated hepatic encephalopathy: a review of literature.遗传缺陷在肉碱相关性肝性脑病中的作用：文献综述
Gastroenterol Hepatol Bed Bench. 2024;17(4):357-378. doi: 10.22037/ghfbb.v17i4.2960.
2
Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity.纯化的、有活性的且对丙二酰辅酶A敏感的大鼠肝脏肉碱棕榈酰转移酶I的重构：膜环境与丙二酰辅酶A敏感性之间的关系
Biochem J. 2000 Jul 1;349(Pt 1):179-87. doi: 10.1042/0264-6021:3490179.
3
The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function.
丙二酰辅酶A-长链酰基辅酶A轴在维持哺乳动物细胞功能中的作用
Biochem J. 1999 Nov 1;343 Pt 3(Pt 3):505-15.
4
Cytological evidence that the C-terminus of carnitine palmitoyltransferase I is on the cytosolic face of the mitochondrial outer membrane.肉碱棕榈酰转移酶I的C末端位于线粒体外膜胞质面的细胞学证据。
Biochem J. 1999 Aug 1;341 ( Pt 3)(Pt 3):777-84. doi: 10.1042/0264-6021:3410777.
5
Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues.肉碱棕榈酰转移酶I同工型的N端和C端结构域在酶对丙二酰辅酶A敏感性中的作用：来自嵌合蛋白表达和保守组氨酸残基突变的见解
Biochem J. 1998 Nov 1;335 ( Pt 3)(Pt 3):513-9. doi: 10.1042/bj3350513.