Migdalis I N, Zachariadis D, Kalogeropoulou K, Nounopoulos C, Bouloukos A, Samartzis M
Department of Diabetes and Medicine, NIMTS Veterans Administration Hospital, Athens, Greece.
Diabet Med. 1996 May;13(5):434-40. doi: 10.1002/(SICI)1096-9136(199605)13:5<434::AID-DIA102>3.0.CO;2-R.
NIDDM appears to be an inherited condition. Our aim was to identify early metabolic abnormalities in non-diabetic offspring with one NIDDM parent and with a strongly positive (n = 58, age 27.8 +/- 7.0 years) or a negative family history (n = 38, age 27.4 +/- 6.7 years) of diabetes. These were compared with 31 offspring of non-diabetic parents (age 26.9 +/- 5.5 years). After an overnight fast, blood was taken for glucose, insulin, C-peptide, insulin receptors, and lipids. All the subjects underwent a 75 g oral glucose tolerance test. The positive family history group had significantly higher fasting levels of triglycerides (1.09 +/- 0.24 vs control subjects: CS: 0.93 +/- 0.16 mmol l-1, p < 0.001), insulin (102.8 +/- 46.4 vs CS: 77.5 +/- 32.4 pmol l-1, p < 0.01) and C-peptide (0.69 +/- 0.22 vs CS: 0.61 +/- 0.19 nmol l-1, p < 0.05) and lower numbers of insulin receptors per red cell (9.1 x 10(3) (4.5-18.1, 95% confidence intervals) vs CS: (11.2 x 10(3) (6.3-19.9)), p < 0.01, despite similar blood glucose levels. After a glucose challenge (120 min), the increases in both insulin and C-peptide concentrations were significantly greater in the positive family history group (289.2 +/- 214.1 pmol l-1, 2.23 +/- 1.48 nmol l-1), respectively, than in CS (192.4 +/- 170.3 pmol l-1, p < 0.05) (1.54 +/- 0.99 nmol l-1 p < 0.01), respectively. No significant differences were found in fasting and post-challenge glucose levels. The negative family history group had significantly lower numbers of insulin receptors 9.4 x 10(3) (4.1-15.2) compared with CS (p < 0.05). Insulin sensitivity was significantly reduced in the positive family history group (41.6%) compared with control subjects (51.9%), p < 0.01. The results strongly support the familial basis of the disease.
非胰岛素依赖型糖尿病（NIDDM）似乎是一种遗传性疾病。我们的目的是确定有一位NIDDM父母且糖尿病家族史呈强阳性（n = 58，年龄27.8 +/- 7.0岁）或阴性（n = 38，年龄27.4 +/- 6.7岁）的非糖尿病后代的早期代谢异常情况。将这些后代与31名非糖尿病父母的后代（年龄26.9 +/- 5.5岁）进行比较。经过一夜禁食后，采集血液检测葡萄糖、胰岛素、C肽、胰岛素受体和血脂。所有受试者均接受75克口服葡萄糖耐量试验。有阳性家族史的组空腹甘油三酯水平显著更高（1.09 +/- 0.24对比对照组：CS：0.93 +/- 0.16 mmol l-1，p < 0.001），胰岛素水平（102.8 +/- 46.4对比CS：77.5 +/- 32.4 pmol l-1，p < 0.01）和C肽水平（0.69 +/- 0.22对比CS：0.61 +/- 0.19 nmol l-1，p < 0.05），且每个红细胞的胰岛素受体数量更少（9.1 x 10(3)（4.5 - 18.1，95%置信区间）对比CS：（11.2 x 10(3)（6.3 - 19.9）），p < 0.01），尽管血糖水平相似。在葡萄糖激发试验后（120分钟），有阳性家族史的组胰岛素和C肽浓度的升高分别显著高于对照组（分别为289.2 +/- 214.1 pmol l-1，2.23 +/- 1.48 nmol l-1），对比CS组（192.4 +/- 170.3 pmol l-1，p < 0.05）（1.54 +/- 0.99 nmol l-1，p < 0.01）。空腹和激发试验后的血糖水平未发现显著差异。有阴性家族史的组胰岛素受体数量显著低于对照组（9.4 x 10(3)（4.1 - 15.2））（p < 0.05）。与对照组（51.9%）相比，有阳性家族史的组胰岛素敏感性显著降低（41.6%），p < 0.01。结果有力地支持了该疾病的家族性基础。
