Guerrer-Romer F, Rodríguez-Morán M, González-Ortiz M, Martínez-Abundis E
Medical Research Unit in Clinical Epidemiology of the Mexican Institute of Social Security, Durango.
J Endocrinol Invest. 2001 Sep;24(8):580-6. doi: 10.1007/BF03343898.
The aim of this study was to assess the early insulin secretion and insulin action of healthy non-diabetic Hispanic-Mexican subjects with and without family history of Type 2 diabetes (FHD). One hundred and twenty non-relative subjects were compared against 115 first-degree relatives of individuals with Type 2 diabetes. To assign the subjects to the correspondent group, the FHD was carefully ascertained by clinical examination of the participants' parents. Age and gender were matched criteria. Incomplete or unclear data about FHD, previous diagnosis of diabetes or chronic diseases were exclusion criteria. Subjects in both groups were required to have fasting glucose <6.1 mmol/l, and 2-h PG<7.7 mmol/l. Insulin action and secretion were estimated by HOMA (homeostasis model insulin analysis resistance index) and insulinogenic index, respectively. Logistic regression analysis showed an independent relationship between BMI and insulin resistance (HOMA score >5.0) (odds ratio, OR, 1.42, p=0.03), and between FHD and insulin resistance (OR 1.27, p=0.04). On the other hand, there was a strong and independent relationship between FHD and high early insulin secretion (insulinogenic index >0.72) (OR 1.64, p=0.01) but not between BMI and high early insulin secretion (OR 0.93, p=0.3). Healthy Mexican first-degree relatives of subjects with Type 2 diabetes show an independent relationship between FHD and both high early insulin response and decreased insulin action, whereas BMI was only related to insulin resistance.
本研究的目的是评估有无2型糖尿病家族史（FHD）的健康非糖尿病西班牙裔墨西哥受试者的早期胰岛素分泌和胰岛素作用。将120名非亲属受试者与115名2型糖尿病患者的一级亲属进行比较。为了将受试者分配到相应组，通过对参与者父母的临床检查仔细确定FHD。年龄和性别为匹配标准。FHD、既往糖尿病诊断或慢性病的不完整或不明确数据为排除标准。两组受试者均要求空腹血糖<6.1 mmol/l，餐后2小时血糖<7.7 mmol/l。分别通过HOMA（稳态模型胰岛素分析抵抗指数）和胰岛素生成指数评估胰岛素作用和分泌。逻辑回归分析显示BMI与胰岛素抵抗（HOMA评分>5.0）之间存在独立关系（优势比，OR，1.42，p=0.03），FHD与胰岛素抵抗之间也存在独立关系（OR 1.27，p=0.04）。另一方面，FHD与高早期胰岛素分泌（胰岛素生成指数>0.72）之间存在强烈的独立关系（OR 1.64，p=0.01），但BMI与高早期胰岛素分泌之间不存在这种关系（OR 0.93，p=0.3）。2型糖尿病患者的健康墨西哥一级亲属显示FHD与高早期胰岛素反应和胰岛素作用降低之间存在独立关系，而BMI仅与胰岛素抵抗有关。
