预防性锂盐与人格变量。一项国际合作研究。

Prophylactic lithium and personality variables. An international collaborative study.

作者信息

Bonetti U, Johansson F, von Knorring L, Perris C, Strandman E

出版信息

Int Pharmacopsychiatry. 1977;12(1):14-9. doi: 10.1159/000468281.

Abstract

61 patients - 28 suffering from bipolar, and 33 from unipolar psychotic affective disorders - completed two personality inventories, one before and one about 6 months after starting lithium treatment to prevent relapses. On the basis of empirical observations it had been assumed that personality characteristics would change more in bipolar than in unipolar patients and that these changes would concern mainly those personality characteristics which reflect sociability and impulsivity. The inventories used were the EPI and the MNT. The results were in agreement with the predictions. Moreover, a significant decrease in N-scores was found both in bipolar and unipolar patients. It is assumed that these changes reflect both the therapeutic effect of lithium and an effect upon the personality characteristics of patients who suffer from bipolar or unipolar affective disorders.

摘要

61名患者——28名患有双相情感障碍，33名患有单相精神病性情感障碍——完成了两份人格量表测试，一份在开始锂盐治疗以预防复发之前，另一份在开始治疗约6个月后。基于实证观察，研究者假定双相情感障碍患者的人格特征变化比单相情感障碍患者更大，且这些变化主要涉及反映社交性和冲动性的人格特征。所使用的量表是艾森克人格问卷（EPI）和明尼苏达多项人格测验（MNT）。结果与预测相符。此外，双相情感障碍患者和单相情感障碍患者的N分均显著降低。据推测，这些变化既反映了锂盐的治疗效果，也反映了对双相或单相情感障碍患者人格特征的影响。