精神科药物对解脲棒状杆菌（棒状杆菌D2群）的体外活性。
In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2).
作者信息
Muñoz-Bellido J L, Muñoz-Criado S, García-Rodríguez J A
机构信息
Departamento de Microbiología y Parasitología, Hospital Universitario de Salamanca, Spain.
出版信息
J Antimicrob Chemother. 1996 May;37(5):1005-9. doi: 10.1093/jac/37.5.1005.
We tested the in-vitro activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline, norfloxacin, ciprofloxacin, vancomycin, teicoplanin, clindamycin and five psychiatric drugs (chlorpromazine, sertraline, fluoxetine, paroxetine and risperidone) against 32 strains of Corynebacterium urealyticum. Resistance rates exceeded 90% for all antibiotics except glycopeptides, quinolones and tetracycline. Sertraline was the most active psychiatric drug. We tested the influence of sertraline on the activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline and ciprofloxacin. We did not observe antagonism in any case. Sertraline enhanced the activity of ciprofloxacin and tetracycline against all strains (MIC decrease: 4-64-fold for ciprofloxacin, 2-32-fold for tetracycline).
我们测试了阿莫西林、阿莫西林/克拉维酸、头孢噻肟、庆大霉素、甲氧苄啶-磺胺甲恶唑、四环素、诺氟沙星、环丙沙星、万古霉素、替考拉宁、克林霉素以及五种精神科药物（氯丙嗪、舍曲林、氟西汀、帕罗西汀和利培酮）对32株解脲棒状杆菌的体外活性。除糖肽类、喹诺酮类和四环素外，所有抗生素的耐药率均超过90%。舍曲林是活性最强的精神科药物。我们测试了舍曲林对阿莫西林、阿莫西林/克拉维酸、头孢噻肟、庆大霉素、甲氧苄啶-磺胺甲恶唑、四环素和环丙沙星活性的影响。在任何情况下均未观察到拮抗作用。舍曲林增强了环丙沙星和四环素对所有菌株的活性（环丙沙星的最低抑菌浓度降低4至64倍，四环素降低2至32倍）。
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