Mercatello A, Jaber K, Hillaire-Buys D, Coronel B, Berland J, Despaux E
Department of Nephrology, Hôpital Ed. Herriot, Lyon, France.
J Antimicrob Chemother. 1996 May;37(5):1017-21. doi: 10.1093/jac/37.5.1017.
We examined the adequacy of the following schedule for the administration of i.v. teicoplanin to patients with chronic renal failure: three doses of 6 mg/kg at 12 h intervals, a fourth dose 24 h later and then subsequent doses every 72 h. Eight infected patients undergoing dialysis were investigated, with serum antibiotic concentrations measured ten minutes before and one hour after administration. Mean trough concentrations were 6.9 +/- 3.1 mg/L on day two, 9.8 +/- 4.4 mg/L (day three), 9.2 +/- 4.8 mg/L (day six), 10.9 +/- 5.5 mg/L (day nine), 12.1 +/- 6.1 mg/L (day 12) and 14.8 +/- 8.0 mg/L (day 15). The proposed schedule achieved adequate trough serum teicoplanin concentrations by 48 h in six out of eight patients examined. The dosage regimen was well tolerated.
每12小时给予3剂6mg/kg，24小时后给予第4剂，随后每72小时给药1次。对8例接受透析的感染患者进行了研究，在给药前10分钟和给药后1小时测量血清抗生素浓度。第2天的平均谷浓度为6.9±3.1mg/L，第3天为9.8±4.4mg/L，第6天为9.2±4.8mg/L，第9天为10.9±5.5mg/L，第12天为12.1±6.1mg/L，第15天为14.8±8.0mg/L。在所研究的8例患者中，有6例按照建议方案在48小时时达到了足够的替考拉宁血清谷浓度。该给药方案耐受性良好。
