Akamatsu H, Niwa Y, Sasaki H, Asada Y, Horio T
Department of Dermatology, Kansai Medical University, Osaka, Japan.
J Int Med Res. 1996 Mar-Apr;24(2):185-9. doi: 10.1177/030006059602400202.
An in vitro study was carried out to investigate the effect of clarithromycin, a new oral macrolide, on neutrophil reactive oxygen species generation and chemotaxis. It was found that neutrophil-generated O2-, H2O2 and OH. levels were significantly increased by clarithromycin at concentrations of 50 micrograms/ml (P < 0.05). The drug also significantly increased chemotaxis (P < 0.05). These results indicate that clarithromycin may enhance the activation of neutrophils in vivo.
