Song Y M, Li Z X, Shi S
Cardiovascular Research Laboratory, Baotou Medical College, China.
Zhongguo Yao Li Xue Bao. 1996 Jan;17(1):72-4.
To study the effects of the combination of aspirin (Asp) and nifedipine (Nif) on hemodynamics in 8 anesthetized dogs.
Tension time index (TTI), left ventricular work index (LVWI), mean arterial pressure (MAP), and total peripheral vascular resistance (TPVR), femoral artery blood flow (FBF), ventricular systolic pressure (LVSP), maximum of its first derivative (dp/dt(max)), left ventricular end diastolic pressure (LVEDP) and heart rate (HR) were recorded on polygraph and electromagnetic flowmeter.
Asp 5, 10 mg.kg-1, i.v. exerted a significant effect on the hemodynamic indices, wheras Nif 15 micrograms.kg-1, i.v. decreased TTI, LVWI, MAP, and TRVR, increased FBF distinctively, and slightly affected LVSP, dp/dt(max), LVEDP, and HR. The effects of Asp in combination with Nif on hemodynamics were similar to those of Nif alone.
The improvement of cardiovascular function caused by Nif was not affected by the presence of Asp.
研究阿司匹林（Asp）与硝苯地平（Nif）联合应用对8只麻醉犬血流动力学的影响。
用多导生理记录仪和电磁流量计记录张力时间指数（TTI）、左心室作功指数（LVWI）、平均动脉压（MAP）、总外周血管阻力（TPVR）、股动脉血流量（FBF）、心室收缩压（LVSP）、其一阶导数最大值（dp/dt(max)）、左心室舒张末期压力（LVEDP）和心率（HR）。
静脉注射Asp 5、10mg·kg-1对血流动力学指标有显著影响，而静脉注射Nif 15μg·kg-1可降低TTI、LVWI、MAP和TRVR，显著增加FBF，对LVSP、dp/dt(max)、LVEDP和HR有轻微影响。Asp与Nif联合应用对血流动力学的影响与单独应用Nif相似。
Nif对心血管功能的改善不受Asp存在的影响。
