Song Y M, Qin J M, Li Z X, Shi S
Cardiovascular Research Laboratory, Baotou Medical College, China.
Zhongguo Yao Li Xue Bao. 1996 Mar;17(2):189-92.
To study the effects of the combination of aspirin (Asp) and nifedipine (Nif) on mesenteric microcirculation of rats.
Acute microcirculation disturbance (AMD) was produced by high molecular weight dextran (M(r) 480,000, 360 mg.kg-1 i.v.). Arteriole and venule blood flow velocity and diameter (ABFV, VBFV, AD, VD) and blood flow state (BFS) were observed by intravital microcirculation method.
Asp 2.5, 5 mg.kg-1, Nif 0.05, 0.1 mg.kg-1, Asp + Nif (1 + 0.025), (2.5 + 0.05) mg.kg-1, i.v. had the significant increase of 11.1%, 31.3%, 18.5%, 19.3%, 30.5%, 39.8% of ABFV and 12.5%, 25.7%, 12.6%, 15.2%, 29.6%, 36.1% of VBFV respectively, the marked improvement of BFS, and the distinctive increase of 4.3%, 17.9%, 35.9%, 39.7%, 15.2%, 42.8% of AD and 2.2%, 4.2%, 26.2%, 27.4%, 3.4%, 28.9% of VD separately, and got a raise in the number of capillaries. Asp + Nif (1 + 0.025), 2.5 + 0.05) mg.kg-1 i.v. could reverse AMD.
Asp was superior to Nif in the increase of BFV, but Nif was superior to Asp in expansion of blood vessel. Asp in combination with Nif produced marked synergistic action and protection againist AMD.
研究阿司匹林（Asp）与硝苯地平（Nif）联合应用对大鼠肠系膜微循环的影响。
通过静脉注射高分子量右旋糖酐（分子量480,000，360 mg·kg-1）制造急性微循环障碍（AMD）。采用活体微循环观察法观察微动脉和微静脉的血流速度、管径（ABFV、VBFV、AD、VD）及血流状态（BFS）。
静脉注射Asp 2.5、5 mg·kg-1，Nif 0.05、0.1 mg·kg-1，Asp + Nif（1 + 0.025）、（2.5 + 0.05）mg·kg-1后，ABFV分别显著增加11.1%、31.3%、18.5%、19.3%、30.5%、39.8%，VBFV分别显著增加12.5%、25.7%、12.6%、15.2%、29.6%、36.1%，BFS明显改善，AD分别显著增加4.3%、17.9%、35.9%、39.7%、15.2%、42.8%，VD分别显著增加2.2%、4.2%、26.2%、27.4%、3.4%、28.9%，且毛细血管数量增多。静脉注射Asp + Nif（1 + 0.025）、（2.5 + 0.05）mg·kg-1可逆转AMD。
Asp在增加BFV方面优于Nif，但Nif在扩张血管方面优于Asp。Asp与Nif联合应用产生显著协同作用，并对AMD具有保护作用。
