Check J H, Nazari A, Kuhn R, Lauer C
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Clin Exp Obstet Gynecol. 1996;23(2):83-6.
A study was performed to see if the level of serum follicle stimulating hormone (FSH) or luteinizing hormone (LH) obtained in the early follicular phase could predict the number of oocytes retrieved following in vitro fertilization (IVF). For each patient the sera FSH and LH were measured by both an enzyme-linked immunosorbent assay (ELISA) and a radioimmunoassay (RIA) method. With the ELISA method when early follicular phase serum FSH was < or = to the group median (9.0 mIU/mL) 16.5 oocytes were retrieved vs 6.7 when FSH was greater than the median. Comparable values using the median of the RIA assay were 17.5 vs 8.1 oocytes. Similar analysis for serum LH failed to show any relationship between baseline LH and the number of oocytes retrieved. This study thus demonstrates that at least one non-isotopic method is equal to a specific RIA method in distinguishing good from average or poor responders.
开展了一项研究，以确定在卵泡早期获得的血清促卵泡激素（FSH）或促黄体生成素（LH）水平是否能够预测体外受精（IVF）后回收的卵母细胞数量。对于每位患者，均采用酶联免疫吸附测定（ELISA）和放射免疫测定（RIA）方法检测血清FSH和LH。采用ELISA方法时，当卵泡早期血清FSH小于或等于组中位数（9.0 mIU/mL）时，回收的卵母细胞为16.5个，而当FSH大于中位数时，回收的卵母细胞为6.7个。采用RIA测定中位数时，相应的值分别为17.5个和8.1个卵母细胞。对血清LH进行的类似分析未显示基线LH与回收的卵母细胞数量之间存在任何关系。因此，本研究表明，在区分反应良好者与反应一般或较差者方面，至少一种非同位素方法与特定的RIA方法相当。
