Veneri D, Todeschini G, Pizzolo G, Franchini M, Ambrosetti A, Vassanelli A, Bressan F, Diani F
Department of Hematology, University of Verona, Italy.
Clin Exp Obstet Gynecol. 1996;23(2):112-5.
In this case report we describe a case of acute myeloid leukemia (AML; FAB M4) diagnosed in a 27-year-old female at the 20th week of gestation. After informed consent, the patient chose to undergo anti-leukemic treatment without therapeutic abortion. Complete remission was obtained following standard chemotherapy for AML (doxorubicin, cytosin-arabinoside, 6-thioguanine). The patient successively underwent an autologous bone marrow transplant (ABMT). No fetal malformation was observed. Urgent cesarean section was necessary at the 29th gestational week because of the onset of foetal sufferance. Fourteen months after diagnosis and seven months after ABMT the patient died due to relapse of AML. The child is presently 3.5 year old and well. In our opinion, the care of a pregnant woman with acute leukemia is feasible and it needs a multi-specialist effort that is easier to be achieved in a tertiary care institution.
在本病例报告中，我们描述了一例在妊娠20周时被诊断为急性髓系白血病（AML；FAB M4）的27岁女性患者。在获得知情同意后，患者选择接受抗白血病治疗而不进行治疗性流产。采用AML标准化疗方案（阿霉素、阿糖胞苷、6-硫鸟嘌呤）后获得完全缓解。患者随后接受了自体骨髓移植（ABMT）。未观察到胎儿畸形。由于胎儿出现痛苦症状，在妊娠29周时进行了紧急剖宫产。诊断后14个月和ABMT后7个月，患者因AML复发死亡。孩子目前3.5岁，身体健康。我们认为，对患有急性白血病的孕妇进行护理是可行的，这需要多专科的努力，而在三级医疗机构中更容易实现。
