Müller R, Wichmann G, Haufe E
Klinik and Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikums Carl Gustav Carus der Technischen Universität Dresden.
Arzneimittelforschung. 1996 May;46(5):534-8.
After oral administration of 300 mg Sobelin, the efficacy and pharmacological kinetics of clindamycin (CAS 18323-44-9) were analysed in 35 patients with recurrent tonsillitis. Minimal inhibitor concentration (MIC) and minimal bactericidal concentration (MBC) have been evaluated for 120 strains. MIC and MBC for 91.7% of the strains amounted to 0.25 micrograms/ml. Concentrations of antibiotics in the serum were higher than 0.25 micrograms/ml after 12 h, i.e. higher than the minimal inhibitory concentration. The established free and efficient portion of clindamycin in the serum which is not bound to plasma proteins shows that a clear bacteriostatic effect is achieved up to 6 h after application of the antibiotic. The concentration in the tissue of the tonsils was 0.6-0.8 micrograms/g after 7-9 h indicating that sufficient MIC values were achieved. The free portion of the antibiotic in the tissues after 9 h also reached the MIC of germs. Hence clindamycin is considered to be an efficient antibiotic in the management of acute exacerbation of recurrent tonsillitis. Due to serum- and tissue levels of the tonsils administration of 300 mg of the test drug is indicated three times daily.
对35例复发性扁桃体炎患者口服300毫克索贝林后，分析了克林霉素（CAS 18323 - 44 - 9）的疗效和药代动力学。对120株菌株评估了最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。91.7%的菌株的MIC和MBC为0.25微克/毫升。12小时后血清中抗生素浓度高于0.25微克/毫升，即高于最低抑菌浓度。血清中未与血浆蛋白结合的克林霉素的游离有效部分表明，应用抗生素后长达6小时可产生明显的抑菌作用。7 - 9小时后扁桃体组织中的浓度为0.6 - 0.8微克/克，表明达到了足够的MIC值。9小时后组织中抗生素的游离部分也达到了细菌的MIC。因此，克林霉素被认为是治疗复发性扁桃体炎急性加重期的有效抗生素。鉴于扁桃体的血清和组织水平，建议每日三次服用300毫克受试药物。
