Mogyorósi A, Ziyadeh F N
Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, USA.
Curr Opin Nephrol Hypertens. 1996 May;5(3):243-53. doi: 10.1097/00041552-199605000-00010.
Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recommendations center around strict glycemic control and the normalization of blood pressure by angiotensin-converting enzyme inhibitors.
实验动物模型和细胞培养技术突出了葡萄糖代谢的核心作用，为深入了解糖尿病肾病的发病机制提供了重要见解。文中讨论了微量白蛋白尿以及其他疾病早期发作的候选表型或基因型标志物。管理建议主要围绕严格控制血糖以及使用血管紧张素转换酶抑制剂使血压正常化。
