正常大鼠与患格林上皮瘤大鼠的转氨酶活性比较。
The comparison of aminotransferase activities in normal and Guerin epithelioma bearing rats.
作者信息
Jaroszewicz L, Wincewicz A, Rzeczycki W
出版信息
Neoplasma. 1976;23(3):259-63.
The activities of 13 aminotransferawes in Guerin epithelioma and in the liver of normal and tumor bearing rats were investigated. Alanine and aspartate aminotransferases show the highest activity in all investigated tissues. In the liver of normal rats high arginine, tyrosine and phenylalanine aminotransferase activities were found. In tumor tissue high level of branched chain amino acid (leucine, valine and isoleucine) aminotransferases were observed. Increase in aminotransferase activities in the liver of tumor bearing rats was found. In order to elucidate the mechanism of this increase an inductive effect of hydrocortisone and protein free extract of tumor tissue on liver aminotransferases has been investigated. The tumor extract did not exert an inductive action. An inductive effect of hydrocortisone was not identical with the change in aminotransferase activities observed in the liver of tumor bearing rats.
对正常大鼠、荷瘤大鼠肝脏以及格林上皮瘤中13种转氨酶的活性进行了研究。丙氨酸转氨酶和天冬氨酸转氨酶在所有被研究组织中活性最高。在正常大鼠肝脏中，发现精氨酸、酪氨酸和苯丙氨酸转氨酶活性较高。在肿瘤组织中，观察到支链氨基酸（亮氨酸、缬氨酸和异亮氨酸）转氨酶水平较高。发现荷瘤大鼠肝脏中转氨酶活性增加。为了阐明这种增加的机制，研究了氢化可的松和肿瘤组织无蛋白提取物对肝脏转氨酶的诱导作用。肿瘤提取物未发挥诱导作用。氢化可的松的诱导作用与荷瘤大鼠肝脏中观察到的转氨酶活性变化并不相同。
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