促肾上腺皮质激素（4-9）类似物ORG 2766的慢性和杏仁核内给药可调节NMDA受体活性被操纵后的行为变化。

Chronic and intra-amygdala administrations of the ACTH(4-9) analog ORG 2766 modulate behavioral changes after manipulation of NMDA-receptor activity.

作者信息

van Rijzingen I M, Gispen W H, Dam R, Spruijt B M

机构信息

Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands.

出版信息

Brain Res. 1996 Apr 22;717(1-2):200-3. doi: 10.1016/0006-8993(96)00128-x.

DOI:10.1016/0006-8993(96)00128-x

PMID:8738274

Abstract

Microinjection of N-methyl-D-aspartic acid (NMDA, 300 ng/3 microliters) into the left lateral ventricle causes a substantial increase in locomotor activity which can be significantly reduced by a chronic pretreatment with the ACTH(4-9) analogue ORG 2766(1 microgram/0.5 ml saline, subcutaneous (s.c.) every day for 7 days, last injection 24 h before the NMDA-injection). A single dose of ORG 2766 (1 ng/1 microliter) injected into the left central amygdaloid nucleus 30 min before the NMDA-injection was equally effective in reducing the increase in locomotion. Furthermore it counteracted the predominance of contralateral turning induced by the NMDA-injection. The data give support for the idea that ORG 2766 excerts its effects on behavior and neural recovery by modulating NMDA receptor activity in the brain.

摘要

向左脑室微量注射N-甲基-D-天冬氨酸（NMDA，300纳克/3微升）会导致运动活动显著增加，而通过用促肾上腺皮质激素（4-9）类似物ORG 2766进行慢性预处理（1微克/0.5毫升生理盐水，每天皮下注射，共7天，最后一次注射在NMDA注射前24小时），这种增加可被显著降低。在NMDA注射前30分钟，向左杏仁核中央核注射单剂量的ORG 2766（1纳克/1微升）在减少运动增加方面同样有效。此外，它还抵消了NMDA注射所诱导的对侧旋转优势。这些数据支持了ORG 2766通过调节大脑中的NMDA受体活性来发挥其对行为和神经恢复作用的观点。