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强力硬膜外注射治疗术后腰椎脊柱纤维化所致腰腿痛。

Forceful epidural injections for the treatment of lumbosciatic pain with post-operative lumbar spinal fibrosis.

作者信息

Revel M, Auleley G R, Alaoui S, Nguyen M, Duruoz T, Eck-Michaud S, Roux C, Amor B

机构信息

Department of Rehabilitation and Readaptation of Patients with Locomotor and Spinal Disorders, Cochin Teaching Hospital, Paris, France.

出版信息

Rev Rhum Engl Ed. 1996 Apr;63(4):270-7.

PMID:8738446
Abstract

OBJECTIVE

To evaluate the efficacy of forceful epidural corticosteroid injections in lumbosciatic pain ascribed to post-operative lumbar spinal fibrosis.

METHOD

Randomized controlled study comparing forceful injections via the sacral hiatus of 125 mg prednisolone acetate + 40 ml saline (treatment group) and injections via the same route of 125 mg prednisolone acetate alone (control group). Results were compared after six and 18 months. The main evaluation criterion was a subjective assessment of overall efficacy done by the patient using a seven-level scale.

RESULTS

After six months, the proportion of patients who were relieved of their sciatica was significantly higher in the forceful injection group (n = 29; 45%) than in the control group (n = 31; 19%) (p = 0.03). Success rates for low back pain were 29% and 6% in the forceful injection and control groups, respectively. Among secondary efficacy criteria, nerve root pain evaluated on a visual analog scale and by Schöber's index showed significantly greater improvement in the forceful injection group than in the control group. After 18 months, results were still in favor of the forceful injection group, with success rates of 39% for the sciatica and 31% for the low back pain. The proportion of patients who returned to work was similar in the two groups.

CONCLUSION

Although mediocre overall, the results of forceful epidural corticosteroid injections are better than those of simple epidural injections of a corticosteroid alone. Given the paucity of effective treatments for lumbosciatic pain apparently due to postoperative fibrosis, forceful injections should be given a place in the treatment of this condition.

摘要

目的

评估强力硬膜外注射皮质类固醇治疗术后腰椎脊髓纤维化所致腰腿痛的疗效。

方法

随机对照研究,比较经骶裂孔强力注射125mg醋酸泼尼松龙+40ml生理盐水(治疗组)与经同途径单纯注射125mg醋酸泼尼松龙(对照组)。在6个月和18个月后比较结果。主要评估标准是患者使用七级量表对总体疗效进行主观评估。

结果

6个月后,强力注射组(n=29;45%)坐骨神经痛缓解的患者比例显著高于对照组(n=31;19%)(p=0.03)。强力注射组和对照组的腰痛成功率分别为29%和6%。在次要疗效标准中,通过视觉模拟量表和朔贝指数评估的神经根疼痛在强力注射组比对照组有显著更大的改善。18个月后,结果仍有利于强力注射组,坐骨神经痛成功率为39%,腰痛成功率为31%。两组恢复工作的患者比例相似。

结论

尽管总体效果一般,但强力硬膜外注射皮质类固醇的结果优于单纯硬膜外注射皮质类固醇。鉴于对于明显由术后纤维化引起的腰腿痛缺乏有效的治疗方法,可以考虑使用强力注射治疗这种情况。

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