Meixensberger J, Meister T, Janka M, Haubitz B, Bushe K A, Roosen K
Neurochirugische Klinik, Universität Würzburg, Federal Republic of Germany.
Acta Neurochir Suppl. 1996;65:99-101. doi: 10.1007/978-3-7091-9450-8_27.
In a retrospective analysis 385 patients with a histologically defined cranial meningioma were studied to analyze the impact of characteristic factors on morbidity and mortality after modern cranial meningioma surgery. Mortality was 4.2% one month and 7.3% six months after operation. 15.6% of the patients stayed more than one month in the hospital (defined as criteria of operative morbidity). Age, poor preoperative clinical condition (ASA score), intra- and postoperative bleeding and CSF disturbances were significantly associated with a subsequent decrease of quality of life. First symptoms like intracranial hypertension, seizures, aphasia and hemiparesis were correlated with an increase of postoperative Karnowsky index. Postoperative quality of life decreased in patients with optic and other cranial nerve disturbances significantly. Tumour size, location (exception: medial sphenoid wing) and histological diagnosis did not influence surgical outcome. This information may be useful in management decisions regarding asymptomatic meningiomas in elderly and high risk patients.
在一项回顾性分析中，对385例经组织学确诊的颅脑膜瘤患者进行了研究，以分析特征因素对现代颅脑膜瘤手术后发病率和死亡率的影响。术后1个月死亡率为4.2%，6个月死亡率为7.3%。15.6%的患者住院时间超过1个月（定义为手术发病率标准）。年龄、术前临床状况不佳（ASA评分）、术中和术后出血以及脑脊液紊乱与随后的生活质量下降显著相关。颅内高压、癫痫发作、失语和偏瘫等首发症状与术后卡诺夫斯基指数升高相关。视神经和其他颅神经紊乱患者的术后生活质量显著下降。肿瘤大小、位置（蝶骨内侧翼除外）和组织学诊断不影响手术结果。这些信息可能有助于老年和高危患者无症状脑膜瘤的管理决策。
