Hsieh F, Gohh R, Dworkin L
Department of Medicine, Rhode Island Hospital, Providence, USA.
J Am Soc Nephrol. 1996 May;7(5):647-52. doi: 10.1681/ASN.V75647.
Melas (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) is one of a group of heterogeneous yet clinically distinct syndromes ascribed to a defect in mitochondrial function. Here, the case of a patient diagnosed with the MELAS syndrome who subsequently developed acute renal failure is reported. Although no clear renal insult was evident at the time, the clinical picture was consistent with the diagnosis of acute tubular necrosis. The patient's renal function subsequently returned to baseline. This article reviews the literature concerning renal involvement in the mitochondrial encephalomyopathies, including MELAS, and proposes a mechanism by which patients suffering from mitochondrial disorders may be more susceptible to renal hypoxic injury and acute renal failure.
线粒体脑肌病伴乳酸酸中毒和卒中样发作（MELAS）是一组归因于线粒体功能缺陷的异质性但临床特征明显的综合征之一。本文报告了一例诊断为MELAS综合征的患者随后发生急性肾衰竭的病例。尽管当时没有明显的明确肾损伤，但临床表现与急性肾小管坏死的诊断相符。该患者的肾功能随后恢复到基线水平。本文综述了有关线粒体脑肌病（包括MELAS）中肾脏受累的文献，并提出了一种机制，即线粒体疾病患者可能更容易受到肾缺氧损伤和急性肾衰竭的影响。
