Jenkin D
University of Toronto, Toronto-Sunnybrook Regional Cancer Centre, Hospital for Sick Children, Canada.
Oncology (Williston Park). 1996 May;10(5):715-9; discussion 720, 722, 728.
Outcome is described for 1,034 children who received radiation treatment in the management of a brain tumor at the University of Toronto Institutions from 1958 to 1995. The 5-, 10-, 20-, and 30-year relapse-free (or progression-free) survival rates were 47%, 45%, 44%, and 44%, respectively, whereas the corresponding overall survival rates were 52%, 44%, 38%, and 30%. Second malignant tumors became an important cause of death over time, with cumulative incidences of 2.5%, 13%, and 19% at 10, 20, and 30 years, respectively. The 5-year survival rate after the diagnosis of a second malignant tumor was 58%. In general, high-grade tumors, eg, high-grade astrocytomas or brainstem tumors, had a poor 20-year survival rate (18%), compared with low-grade tumors (39% to 47%). Despite improvements in imaging, neurosurgical technique, and radiation treatment, children treated during the last 20 years did not have a significantly improved outcome when compared to children treated earlier.
本文描述了1958年至1995年期间在多伦多大学附属医院接受脑部肿瘤放射治疗的1034名儿童的治疗结果。5年、10年、20年和30年的无复发（或无进展）生存率分别为47%、45%、44%和44%，而相应的总生存率分别为52%、44%、38%和30%。随着时间的推移，第二原发性恶性肿瘤成为重要的死亡原因，10年、20年和30年的累积发病率分别为2.5%、13%和19%。诊断出第二原发性恶性肿瘤后的5年生存率为58%。一般来说，高级别肿瘤，如高级别星形细胞瘤或脑干肿瘤，其20年生存率较差（18%），而低级别肿瘤的20年生存率为39%至47%。尽管在影像学、神经外科技术和放射治疗方面有所改进，但与早期接受治疗的儿童相比，过去20年接受治疗的儿童的治疗结果并没有显著改善。
