Wise R
City Hospital, NHS Trust, Birmingham, England.
J Chemother. 1996 Feb;8 Suppl 2:63-70.
In this review, the methods employed to study tissue penetration are discussed. Mathematical, animal and human models all have their positive and negative features, however studies in man must be central to studying the pharmacokinetics of these agents. The newly introduced parenteral cephalosporins (cefpirome, cefepime and cefoselis) have been studied in man. In general they penetrate tissues to similar extents to other beta-lactam agents. Non-specialised tissues such as inflammatory exudate and peritoneal fluid are rapidly and extensively penetrated. More specialised tissues (such as prostate) are penetrated to a moderate extent (30 to 50%). Certain sites - such as the CSF - are poorly penetrated (c. 5 to 10%). It is important to have a knowledge of this information prior to therapeutic trials of such agents.
在本综述中，讨论了用于研究组织穿透性的方法。数学模型、动物模型和人体模型都有其优缺点，然而人体研究对于这些药物的药代动力学研究至关重要。新引入的肠外头孢菌素（头孢匹罗、头孢吡肟和头孢噻利）已在人体中进行了研究。总体而言，它们在组织中的穿透程度与其他β-内酰胺类药物相似。非特异性组织，如炎性渗出液和腹膜液，能被快速且广泛地穿透。更具特异性的组织（如前列腺）的穿透程度适中（30%至50%）。某些部位，如脑脊液，穿透性较差（约5%至10%）。在对此类药物进行治疗试验之前，了解这些信息很重要。
