乳房切除术后淋巴水肿患者的血液流变学受损。

Impaired hemorheology in patients with postmastectomy lymphedema.

作者信息

Djavanmard M P, Michl I, Korpan M, Fazeny B, Budinsky A C, Wiesinger E, Weinländer G, Binder M, Püspök M, Zielinski C C, Fialka V, Koppensteiner R, Marosi C

机构信息

Department of Internal Medicine I, University of Vienna, Austria, Europe.

出版信息

Breast Cancer Res Treat. 1996;38(3):283-8. doi: 10.1007/BF01806147.

DOI:10.1007/BF01806147

PMID:8739081

Abstract

Lymphedema of the arm is one of the most disabling and serious complications of breast cancer. Apart from tumor infiltration or fibrosis of lymphatic pathways, little is known about factors favoring the development of lymphedema. In the present study, we investigated the impact of rheologic parameters, e.g. red cell aggregation (EA) and plasma viscosity (PV), and of capillary morphology and capillary flow in patients with breast cancer with (n = 18) and without (n = 18) lymphedema. Patients with lymphedema showed a significant increase of red cell aggregation (p < 0.001) that indicates a systemic component of lymphedema and might offer a possibility of prevention and therapy of this condition. A hitherto unclassified protein factor favoring red cell aggregation and lymphedema might be postulated.

摘要

手臂淋巴水肿是乳腺癌最致残且严重的并发症之一。除了肿瘤浸润或淋巴通路纤维化外，关于促进淋巴水肿发展的因素知之甚少。在本研究中，我们调查了血液流变学参数，如红细胞聚集（EA）和血浆黏度（PV），以及乳腺癌伴（n = 18）和不伴（n = 18）淋巴水肿患者的毛细血管形态和毛细血管血流的影响。淋巴水肿患者的红细胞聚集显著增加（p < 0.001），这表明淋巴水肿存在全身因素，可能为这种病症的预防和治疗提供一种可能性。可以推测存在一种迄今未分类的促进红细胞聚集和淋巴水肿的蛋白质因子。