Miyamoto K, Lange M, McKinley G, Stavropoulos C, Moriya S, Matsumoto H, Inada Y
Division of Rheumatology, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY 10025, USA.
Am J Chin Med. 1996;24(1):1-10. doi: 10.1142/S0192415X96000025.
The effects of Sho-saiko-to (SST), a traditional Chinese medicine, on the production of PGE2 from monocytes, LTB4 and superoxide from polymorphonuclear cells (PMNC) in HIV infected individuals were studied. SST inhibited the production of PGE2 from monocytes stimulated by opsonized zymosan in all groups including the healthy control group and also inhibited the production of superoxide from PMNC after stimulation with FMLP. On the other hand, SST enhanced the production of LTB4 when PMNC were stimulated by the calcium ionophore A23187. These results suggest that SST has different effects on the production of prostanoids or superoxide from monocytes and PMNC. Furthermore, our data indicates that inhibition of PGE2 or superoxide production will lead to indirect suppression of HIV, and enhancement of LTB4 will contribute to the upregulation of the immune reaction in HIV infected individuals.
研究了中药小柴胡汤（SST）对HIV感染者单核细胞产生前列腺素E2（PGE2）、多形核细胞（PMNC）产生白三烯B4（LTB4）和超氧化物的影响。SST抑制了包括健康对照组在内的所有组中经调理酵母聚糖刺激的单核细胞产生PGE2，并且在经N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）刺激后抑制了PMNC产生超氧化物。另一方面，当PMNC受到钙离子载体A23187刺激时，SST增强了LTB4的产生。这些结果表明SST对单核细胞和PMNC产生类前列腺素或超氧化物具有不同的影响。此外，我们的数据表明抑制PGE2或超氧化物的产生将导致对HIV的间接抑制，而增强LTB4将有助于上调HIV感染者的免疫反应。
